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Publications

Ian A. White, M.S., Ph.D.

Bellio, M., Farshchian, AJ., White, IA. (in press) Bone Marrow Aspirate and the Use of Autologous Cells and Cellular Products in Regenerative Medicine. Renegerative Medicine: A Complete Guide for Musculoskeletal and Spine Disorders. Springer Nature Publishing.

Tovar, AA., White, IA., Sabater, AL., (in press) Use of Acellular Umbilical Cord-Derived Tissues in Corneal and Ocular Surface Diseases: Special Issue “Stem Cells in Eye Research and Ophthalmology—Current Advances and Future Directions” Medicines.

Gonzalez, MJ., Kweh, MF., Biava, PM., Olalde, J., Toro, AP., Goldschmidt-Clermont, PJ., White, IA. (in press) Evaluation of Exosome Derivatives as Bio-Informational Reprogramming Therapy for Cancer. Journal of Translational Medicine.

Arora, H., Lavin, AC., Balkan, W., Hare, JM., White, IA. (in press) Neuregulin-1, in a Conducive Milieu with Wnt/Bmp/Retinoic Acid, Prolongs the Epicardial-Mediated Cardiac Regeneration Capacity of Neonatal Heart Explants. Stem Cells & Regenerative Medicine.

White IA. (2020)The Potential of Amniotic Fluid-Derived Extracellular Vesicles to Treat Severe Acute Respiratory Syndrome Coronavirus 2 Infection Versus Hydroxychloroquine in Human Patients.Epidemiology OJ.; 5(1):8-12.Goldschmidt-Clermont, PJ., DiFede, DL., White IA. (2019) Amniotic Exosomes and Pregnancy. eLetter. Science Translational Medicine. Vol 11, issue 492.

White IA, Sebater, AL. (2018) Current Strategies for Human Corneal Endothelial Tissue Regeneration.Regenerative Medicine. May. 14(4):257-261.

White, IA. (2016) Cardiac Sympathetic Denervation in the Failing Heart: A Role for Epicardial Adipose Tissue. Circulation Research. April 14:118,1189-1191.

White, IA., Sanina, C., Balkan, W., Hare, JM. (2016) Mesenchymal stem cells and cardiology. Methods in Molecular Biology, Springer Publishing, NY.

White, IA., Gordon, J., Balkan W., Hare, JM. (2015) Sympathetic Reinnervation is Required for Mammalian Cardiac Regeneration. Circulation Research. Dec 4;117(12):990-4.

Hatzistergos, KE., Takeuchi, LM., Saur, M., Dymecki, SM., Mai, JJ., White, IA., Balkan, W., Kanashiro- Takeuchi, RM., Hare, JM. cKit+ Cardiac Progenitors of Neural Crest Origin. PNAS, 2015:20;112 (42):13051-6.

Westerweel, PE., Teraa, M., Rafii, S., White, IA., Hooper, AT., Doevendans, PA., Verhaar, MC. Impaired Endothelial progenitor cell mobilization due to bone marrow vascular niche dysfunction in diabetes mellitus. PLoS One. 2013;8.

Butler JM, Nolan DJ, Vertes EL, Varnum-Finney B, Kobayashi H, Hooper AT, Seandel M, Shido K, White IA, Kobayashi M, Witte L, May C, Shawber C, Kimura Y, Kitajewski J, Rosenwaks Z, Bernstein ID, Rafii S. Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. Cell Stem Cell. (2010) Mar 5;6(3):251-64.

Seandel M, Butler JM, Kobayashi H, White IA, Rafii, S. Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene . Proc Natl Acad Sci USA. (2008) Dec 9; 105(49).

Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, St Clair R, Baljevic M, White I, Jin DK, Chadburn A, Murphy AJ, Valenzuela DM, Gale NW, Thurston G, Yancopoulos GD, D’Angelica M, Kemeny N, Lyden D, Rafii S. CD133 expression is not restricted to stem cells, and both CD133+ and CD133-metastatic colon cancer cells initiate tumors. J Clin Invest. 2008 Jun;118(6):2111-20.

Peng, S.L., Townsend, M.J., Hecht, J.L., White, IA., Glimcher, L.H. (2004) T-bet Regulates Metastasis Rate in a Murine Model of Primary Prostate Cancer. Cancer Research 64:452-455. 

Miaw, S-C., Kang, B.Y., White, IA., Ho, I-C. (2004) A Repressor of GATA-Mediated Negative Feedback Mechanism of T Cell Activation. The Journal of Immunology 172:170-177. 

Hwang, E-S., White, IA., Ho, I-C. (2002). An IL-4-independent and CD25-mediated function of c-maf in promoting the production of Th2 cytokines. Proc Natl Acad Sci U S A. 1;99(20):13026-30.

Mercedes Kweh, Ph.D.

Gonzalez, MJ., Kweh, MF., Biava, PM., Olalde, J., Toro, AP., Goldschmidt-Clermont, PJ., White, IA. (in press) Evaluation of Exosome Derivatives as Bio-Informational Reprogramming Therapy for Cancer. Journal of Translational Medicine.

Kweh, MF., Merriman, KE., Wells, T., Nelson, CD. (in press) Vitamin D Signaling Increases Nitric Oxide and Antioxidant Defenses of Bovine Monocytes. J Dairy Sci.

Rajan, SS., Amin, AD., Li, L., Rolland, DC., Li, H., Kwon, D., Kweh, MF., Arumov, A., Roberts, ER., Yan, A., Basrur, V., Elenitoba-Johnson, KSJ., Chen, XS., Puvvada, SD., Lussier, YA., Bilbao, D., Lim, MS., Schatz, JH. (2020) The Mechanism of Cancer Drug Addiction in ALK-Positive T-Cell Lymphoma. Oncogene. Mar;39(10):2103-2117.

Poindexter, MB., Kweh, MF., Zimpel, R., Zuniga, J., Lopera, C., Zenobi, MG., Jiang, Y., Engstrom, M., Celi, P., Santos, JEP., Nelson, CD. (2020) Feeding Supplemental 25-Hydroxyvitamin D3 Increases Serum Mineral Concentrations and Alters Mammary Immunity of Lactating Dairy Cows.  J Dairy Sci. 2020 Jan;103(1):805-822.

Rajan, SS., Li, L., Kweh, MF., Kunkalla, K., Amin, AD., Agarwal, NK., Vega, F., Schatz, JH. (2019) CRISPR Genome Editing of Murine Hematopoietic Stem Cells to Create Npm1-Alk Causes ALK+ Lymphoma After Transplantation. Blood Adv. Jun 25;3(12):1788-1794.

Kweh, MF., Merriman, KE., Nelson, CD. (2019) Inhibition of DNA Methyltransferase and Histone Deacetylase Increases Β-Defensin Expression but Not the Effects of Lipopolysaccharide or 1,25-dihydroxyvitamin D3 in Bovine Mammary Epithelial Cells.  J Dairy Sci. Jun;102(6):5706-5712.

Nelson, CD., Merriman, KE., Poindexter, MB., Kweh, MF., Blakely, LP. (2018) Symposium Review: Targeting Antimicrobial Defenses of the Udder Through an Intrinsic Cellular Pathway. J Dairy Sci. Mar;101(3):2753-2761.

Merriman, KE., Poindexter, MB., Kweh, MF., Santos, JEP., Nelson, CD. (2017) Intramammary 1,25- dihydroxyvitamin D3 Treatment Increases Expression of Host-Defense Genes in Mammary Immune Cells of Lactating Dairy Cattle. J Steroid Biochem Mol Biol. Oct;173:33-41.

Venkatesh, P., Phillippi, J., Chukkapalli, S., Rivera-Kweh, M., Velsko, I., Gleason, T., VanRyzin, P., Aalaei-Andabili, SH., Ghanta, RK., Beaver, T., Chan, EKL., Kesavalu, L. (2017) Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms. Int J Mol Sci. Apr 20;18(4).

Aguirre, JI., Akhter, MP., Neuville, KG., Trcalek, CR., Leeper, AM., Williams, AA., Rivera, M., Kesavalu, L., Ke, HZ., Liu, M., Kimmel, DB. (2017) Age-Related Periodontitis and Alveolar Bone Loss in Rice Rats. Arch Oral Biol. Jan;73:193-205.

Chukkapalli, SS., Easwaran, M., Rivera-Kweh, MF., Velsko, IM., Ambadapadi, S., Dai, J., Larjava, H., Lucas, AR., Kesavalu, L. (2017) Sequential Colonization of Periodontal Pathogens in Induction of Periodontal Disease and Atherosclerosis in LDLRnull Mice . Pathog Dis. Jan 1;75(1).

Chukkapalli, S., Rivera-Kweh, M., Gehlot, P., Velsko, I., Bhattacharyya, I., Calise, SJ., Satoh, M., Chan, EK., Holoshitz, J., Kesavalu, L. (2016) Periodontal Bacterial Colonization in Synovial Tissues Exacerbates Collagen-Induced Arthritis In B10.RIII Mice. Arthritis Res Ther. Jul 12;18(1):161.

Chukkapalli, SS., Velsko, I​M., Rivera-Kweh, M., Larjava, H., Lucas, AR., Kesavalu, L. (2017) Global Tlr2 and 4 Deficiency in Mice Impacts Bone Resorption, Inflammatory Markers and Atherosclerosis to Polymicrobial Infection. Mol Oral Microbiol.  Jun;32(3):211-225.

Turner, RT., Dube, M., Branscum, AJ., Wong, CP., Olson, DA., Zhong, X., Kweh, MF., Larkin, IV., Wronski, TJ., Rosen, CJ., Kalra, SP., Iwaniec, UT. (2015) Hypothalamic Leptin Gene Therapy Reduces Body Weight Without Accelerating Age-Related Bone Loss.  Endocrinol. Dec;227(3):129-41.

Velsko, IM., Chukkapalli, SS., Rivera-Kweh, MF., Zheng, D., Aukhil, I., Lucas, AR., Larjava, H., Kesavalu, L. (2015) Periodontal Pathogens Invade Gingiva and Aortic Adventitia and Elicit Inflammasome Activation in Αvβ6 Integrin-Deficient Mice.  Infect Immun. Dec;83(12):4582-93.

Poole, S., Singhrao, SK., Chukkapalli, S., Rivera, M., Velsko, I., Kesavalu, L., Crean, S. (2015) Active Invasion of Porphyromonas gingivalis and Infection-Induced Complement Activation in ApoE-/- Mice Brains. J Alzheimers Dis.;43(1):67-80.

Merriman, KE., Kweh, MF., Powell, JL., Lippolis, JD., Nelson, CD. (2015)  Multiple Β-Defensin Genes Are Upregulated by the Vitamin D Pathway in Cattle. J Steroid Biochem Mol Biol. Nov;154:120-9.

Chukkapalli, SS., Velsko, IM., Rivera-Kweh, MF., Zheng, D., Lucas, AR., Kesavalu, L. (2015) Polymicrobial Oral Infection with Four Periodontal Bacteria Orchestrates a Distinct Inflammatory Response and Atherosclerosis in ApoE Null Mice.  PLoS One. Nov 30;10(11):e0143291.

Velsko, IM., Chukkapalli, SS., Rivera-Kweh, MF., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, PR., Lucas, AR., Kesavalu, L. (2015) Fusobacterium nucleatum Alters Atherosclerosis Risk Factors and Enhances Inflammatory Markers with an Atheroprotective Immune Response in ApoE(Null) Mice.  PLoS One. Jun 16;10(6):e0129795.

Gangula, P., Ravella, K., Chukkapalli, S., Rivera, M., Srinivasan, S., Hale, A., Channon, K., Southerland, J., Kesavalu, L. (2015) Polybacterial Periodontal Pathogens Alter Vascular and Gut BH4/Nnos/NRF2-Phase II Enzyme Expression. PLoS One. Jun 25;10(6):e0129885.

Chukkapalli, SS., Rivera-Kweh, MF., Velsko, IM., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, PR., Lucas, AR, Kesavalu, L. (2015) Chronic Oral Infection with Major Periodontal Bacteria Tannerella forsythia Modulates Systemic Atherosclerosis Risk Factors and Inflammatory Markers.  Pathog Dis. Apr;73(3):ftv009.

Oktay, S., Chukkapalli, SS., Rivera-Kweh, MF., Velsko, IM., Holliday, LS., Kesavalu, L. (2015) Periodontitis in Rats Induces Systemic Oxidative Stress That is Controlled by Bone-Targeted Antiresorptives. J Periodontol. Jan;86(1):137-45.

Velsko, IM., Rivera, MF., Chukkapalli, SS., Lee, JY., Chen, H., Bhattacharyya, I., Gangula, P., Lucas, AR., Kesavalu, L. (2014) Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis. PLoS One. May 16;9(5):e97811.

Lucas, AR., Verma, RK., Dai, E., Liu, L., Chen, H., Kesavalu, S., Rivera, M., Velsko, I., Ambadapadi, S., Chukkapalli, S., Kesavalu, L. (2014) Myxomavirus Anti-Inflammatory Chemokine Binding Protein Reduces the Increased Plaque Growth Induced by Chronic Porphyromonas gingivalis Oral Infection After Balloon Angioplasty Aortic Injury in Mice.  PLoS One. Oct 29;9(10):e111353.

Rivera, MF., Chukkapalli, SS., Velsko, IM., Lee, JY., Bhattacharyya, I., Dolce, C., Toro, EJ., Holliday, LS., Kesavalu, L. (2014) Bis-Enoxacin Blocks Rat Alveolar Bone Resorption from Experimental Periodontitis. PLoS One. Mar 17;9(3):e92119.

Chukkapalli, SS., Rivera, MF., Velsko, IM., Lee, JY., Chen, H., Zheng, D., Bhattacharyya, I., Gangula, PR., Lucas, AR., Kesavalu, L. (2014) Invasion of Oral and Aortic Tissues by Oral Spirochete Treponema denticola in ApoE-/- Mice Causally Links Periodontal Disease and Atherosclerosis.  Infect Immun. May;82(5):1959-67.

Rivera. MF., Lee, JY., Aneja, M., Goswami, V., Liu, L., Velsko, IM., Chukkapalli, SS., Bhattacharyya, I., Chen, H., Lucas, AR., Kesavalu, LN. (2013) Polymicrobial Infection with Major Periodontal Pathogens Induced Periodontal Disease and Aortic Atherosclerosis in Hyperlipidemic ApoE(Null) Mice.  PLoS One.; 8(2):e57178.

Toro, EJ., Zuo, J., Gutierrez, A., La Rosa, RL., Gawron, AJ., Bradaschia-Correa, V., Arana-Chavez, V., Dolce, C., Rivera, MF., Kesavalu, L., Bhattacharyya, I., Neubert, JK., Holliday, LS. (2013) Bis-Enoxacin Inhibits Bone Resorption and Orthodontic Tooth Movement. J Dent Res. Oct;92(10):925-31.

Nahid, MA., River, M., Lucas, A., Chan, E., Kesavalu, L. (2011) Polymicrobial Infection with Periodontal Pathogens Specifically Enhances Mir-146a in ApoEnull Mice During Experimental Periodontal Disease.  Infect. Immun. Apr;79(4):1597-605.

Bainbridge, B., Verma, RK., Eastman, C., Yehia, B., Rivera, M., Moffatt, C., Bhattacharyya, I., Lamont, RJ., Kesavalu, L. (2010) Role of Porphyromonas gingivalis Phosphoserine Phosphatase Enzyme Serb in Inflammation, Immune Response and Induction of Alveolar Bone Resorption in Rats.  Infect. Immun. Nov;78(11):4560-9.

Phillips, JA., Almeida, EA., Hill, EL., Aguirre, JI., Rivera, MF., Nachbandi, I., Wronski, TJ., van der Meulen MC., Globus, RK. (2008) Role for Β1 Integrins in Cortical Osteocytes During Acute Musculoskeletal Disuse. Matrix Biol. Sep;27(7):609-18.

Abranches, J., Nascimento, MM., Zeng, L., Browngardt, CM., Wen, ZT., Rivera, MF., Burne, RA. (2008) Ccpa Regulates Central Metabolism and Virulence Gene Expression in Streptococcus mutans. J Bacteriol. Apr;190(7):2340-9.

Aguirre, I., Leal, ME., Rivera, MF., Vanegas, SM., Jorgensen, M., Wronski, TJ. (2007) Effects of Basic Fibroblast Growth Factor and a Prostaglandin E2 Receptor Subtype 4 Agonist on Osteoblastogenesis and Adipogenesis in Aged Ovariectomized Rats. J Bone Miner Res. Jun;22(6):877-88.

Iwaniec, UT., Wronski, TJ., Liu, J., Rivera, MF., Arzaga, R., Rice, DS., Brommage, GB. (2007) Parathyroid Hormone Stimulates Bone Formation in Mice Deficient in Lrp5. J Bone Miner Res. Mar;22(3):394-402.

Iwaniec, UT., Moore, K., Rivera, MF., Myers, SE., Vanegas, SM., Wronski, TJ. (2007) A Comparative Study of the Bone-Restorative Efficacy of Anabolic Agents in Aged Ovariectomized Rats. Osteoporos Int. Mar;18(3):351-62.

Pascal J. Goldschmidt-Clermont, MD

Frederick M. Rauscher, MD; Pascal J. Goldschmidt-Clermont, MD; Bryce H. Davis, BSE*; Tao Wang, MD, PhD*; David Gregg, MD; Priya Ramaswami, BE; Anne M. Pippen, BS; Brian H. Annex, MD; Chunming Dong, MD; Doris A. Taylor, Ph.D; Aging, Progenitor Cell Exhaustion, and AtherosclerosisAHA/AJS Journals

.Pascal J. Goldschmidt-Clermont, MD, Darcy L DiFede, Ian A. White, Ph.D. Amniotic Extracellular Vesicles IntroductionScience Translation Medicine.

Ravi Karra, Sreekanth Vemullapalli, Chunming Dong, Edward E. Herderick, Xiaohua Song, Kathy Slosek, Joseph R. Nevins, Mike West, Pascal J. Goldschmidt-Clermont, and David Seo. Molecular evidence for arterial repair in atherosclerosisPNAS.

Pascal Goldschmidt-Clermont; Pregnancy & Amniotic Extracellular Vesicles Landmark, Frontiers in Bioscience-Landmark

Pascal J. Goldschmidt-Clermont, MD; Mark A. Creager, MD; Douglas W. Lorsordo, MD; Gregory K.W. Lam, MD; Momtaz Wassef, PhD; Victor J. Dzau, MD; Atherosclerosis 2005-  Recent Discoveries and Novel Hypotheses; AHA/AJS Journals.

Shoukang Zhu, Shanming Deng, Qi Ma, Taifang Zhang, Chunling Jia, Degen Zhuo, Falin Yang, Jianqin Wei, Liyong Wang, Derek M. Dykxhoorn, Joshua M. Hare, Pascal J. Goldschmidt-Clermont, Chunming Dong; MicroRNA-10A* and MicroRNA-21 Modulate Endothelial Progenitor Cell Senescence Via Suppressing High-Mobility Group A2AHA/AJS Journals.

Trajen Head, Sylvia Daunert, and Pascal J. Goldschmidt-Clermont; The Aging Risk and Atherosclerosis: A Fresh Look at Arterial Homeostasis; Frontiers in Genetics.